Department of Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Brazil.
Am J Orthod Dentofacial Orthop. 2012 Sep;142(3):333-8. doi: 10.1016/j.ajodo.2012.04.011.
Asthma is a common systemic disease occurring in infancy and adolescence, time periods that could encompass orthodontic treatment. Asthma is an inflammatory disease; therefore, it might interfere with orthodontic tooth movement. The purpose of the study was to analyze the histomorphologic aspects of the periodontal ligament of asthmatic Wistar rats in the initial period of orthodontic movement.
Thirty-two Wistar rats were divided into 4 groups: 2 control groups consisting of rats without induced allergic asthma, and 2 experimental groups consisting of rats with induced allergic asthma. The animals of the first control and experimental groups did not receive orthodontic forces, whereas those in the second control and experimental groups were subjected to mesial movement of the maxillary left first molar for 3 days. The samples were prepared for histomorphometric analysis of the periodontal ligament. The area of the periodontal ligament was calculated as a function of root length in the cervical and apical regions of the distal face of the maxillary first molar mesial root. The Student t test and the Welch correlation test were applied to the data obtained.
There was a statistically significant difference (P <0.05) between the control and experimental groups. An enhanced response to orthodontic force was observed in the asthmatic animals: the periodontal ligament was more compressed at the pressure area and more stretched in the traction area.
Our findings indicate that experimental allergic asthma seems to exacerbate orthodontic movement in rats.
哮喘是一种常见的在婴幼儿和青少年时期发生的系统性疾病，这个时期可能包括正畸治疗。哮喘是一种炎症性疾病；因此，它可能会干扰正畸牙齿移动。本研究的目的是分析哮喘 Wistar 大鼠在正畸运动初始期牙周韧带的组织形态学方面。
将 32 只 Wistar 大鼠分为 4 组：2 个对照组由未诱导过敏性哮喘的大鼠组成，2 个实验组由诱导过敏性哮喘的大鼠组成。第一对照组和实验组的动物未接受正畸力，而第二对照组和实验组的动物则接受左侧上颌第一磨牙近中移动 3 天。制备牙周韧带的组织形态计量学分析样本。将牙周韧带的面积作为上颌第一磨牙近中根远端面颈区和根尖区根长的函数进行计算。对获得的数据应用学生 t 检验和 Welch 相关检验。
对照组和实验组之间存在统计学显著差异（P <0.05）。哮喘动物对正畸力的反应增强：在压力区牙周韧带被更压缩，在牵引区被更拉伸。
我们的发现表明，实验性过敏性哮喘似乎会加重大鼠的正畸运动。
