Lebeaux David, Ghigo Jean-Marc
Institut Pasteur, Unité de Génétique des Biofilms, Département de Microbiologie, 75015 Paris, France.
Med Sci (Paris). 2012 Aug-Sep;28(8-9):727-39. doi: 10.1051/medsci/2012288015. Epub 2012 Aug 22.
Biofilms are surface-associated microbial communities present in all environments. Although biofilms play important ecological roles, they also lead to negative or deleterious effects in industrial and medical settings. In the latter, high levels of antibiotic tolerance of bacterial biofilms developing on medical devices and during chronic infections determine the physiopathology of many healthcare-associated infections. Original approaches have been developed to avoid bacterial adhesion or biofilm development targetting specific mechanisms or pathways. We herein review recent data about biofilm lifestyle understanding and ways to fight against related infections.
生物膜是存在于所有环境中的与表面相关的微生物群落。尽管生物膜发挥着重要的生态作用，但它们在工业和医疗环境中也会导致负面或有害影响。在医疗环境中，医疗器械上形成的细菌生物膜以及慢性感染期间的高抗生素耐受性决定了许多医疗相关感染的病理生理学。人们已经开发出了针对特定机制或途径来避免细菌粘附或生物膜形成的原始方法。我们在此回顾了关于生物膜生活方式理解以及对抗相关感染方法的最新数据。
