丹参对冠状动脉狭窄患者左心室舒张功能的影响

[Effect of Salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis].

作者信息

Xu H T, Chen S L, Li L S

机构信息

Cardiological Department of the Naval Hospital, Beijing.

出版信息

Zhong Xi Yi Jie He Za Zhi. 1990 Dec;10(12):737-9, 710.

PMID:2292121

Abstract

In 24 open-chest mongrel dogs, coronary artery critical stenosis were produced by a micrometer constriction on left circumflex coronary artery. It was reduction about 87% in lumen area. CBF, -Vce, -dp/dt max were decreased, T was increased (P less than 0.01). 15 minutes after stenosis, the Salvia miltiorrhiza injection was injected into left atrium. CBF, -dp/dt max, -Vce were increased and T was decreased after the injection of Salvia miltiorrhiza. Moreover, the change of CBF was the earliest. The results proved that the Salvia miltiorrhiza could improve the left ventricular diastolic function in coronary artery stenosis.

摘要

在24只开胸杂种犬中，通过用测微计对左旋冠状动脉进行缩窄来造成冠状动脉临界狭窄。管腔面积减少了约87%。冠状动脉血流量（CBF）、左室舒张末期容积变化率（-Vce）、左室内压最大上升速率（-dp/dt max）降低，射血时间（T）延长（P<0.01）。狭窄15分钟后，将丹参注射液注入左心房。注射丹参后，CBF、-dp/dt max、-Vce增加，T缩短。而且，CBF的变化最早出现。结果证明，丹参能改善冠状动脉狭窄时的左室舒张功能。