Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.
Int J Gynaecol Obstet. 2012 Dec;119(3):270-3. doi: 10.1016/j.ijgo.2012.06.010. Epub 2012 Aug 24.
To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature.
Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients.
Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 ± 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n=13).
Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially.
分析在土耳其妇科肿瘤中心接受治疗的早期子宫内膜癌（EC）患者的保留生育力治疗结果，并对文献进行回顾。
联系了土耳其的 13 家医疗机构，以确定它们是否有资格参与研究。有资格并同意参与的中心会收到一份数据库表格，以记录其 EC 患者的人口统计学特征、临床病理发现和随访结果。
11 家土耳其医疗机构提供了 43 名 EC 患者的数据。平均治疗时间为 5 个月，平均随访时间为 49 个月。在接受孕激素初次治疗后，有 35 名（81.4%）患者肿瘤消失。从孕激素治疗结束到怀孕的平均时间为 10.6±4.3 个月（范围为 3-18 个月）。在随访期间有 2 名患者肿瘤复发。31 名积极寻求怀孕的女性的妊娠率为 41.9%（n=13）。
在有生育能力的年轻女性中使用口服孕激素对早期 EC 进行保守治疗是有效的，且不会影响肿瘤学结局。研究患者的妊娠是自然和人工获得的。
