TGF-β and renal fibrosis: a Pandora's box of surprises.
作者信息
Kanwar Yashpal S
机构信息
Department of Pathology and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
出版信息
Am J Pathol. 2012 Oct;181(4):1147-50. doi: 10.1016/j.ajpath.2012.08.002. Epub 2012 Aug 21.
Abstract
摘要
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本文引用的文献
1
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.溶血磷脂酸通过 LPA2 和 Gαq 介导的 Rho 和 αvβ6 整合素依赖性 TGF-β 的激活，增加近端肾小管细胞分泌促纤维化细胞因子 PDGF-B 和 CTGF。
Am J Pathol. 2012 Oct;181(4):1236-49. doi: 10.1016/j.ajpath.2012.06.035. Epub 2012 Aug 10.
2
Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis.靶向近端肾小管损伤引发间质纤维化和肾小球硬化。
Kidney Int. 2012 Jul;82(2):172-83. doi: 10.1038/ki.2012.20. Epub 2012 Mar 21.
3
PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.PTEN 缺失定义了 TGF-β 诱导的肾小管分化失败表型和肾纤维化过程中的 JNK 信号通路。
Am J Physiol Renal Physiol. 2012 May 1;302(9):F1210-23. doi: 10.1152/ajprenal.00660.2011. Epub 2012 Feb 1.
4
EGFR signaling promotes TGFβ-dependent renal fibrosis.EGFR 信号通路促进 TGFβ 依赖的肾脏纤维化。
J Am Soc Nephrol. 2012 Feb;23(2):215-24. doi: 10.1681/ASN.2011070645. Epub 2011 Nov 17.
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Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.整联蛋白 αVβ3 介导的自分泌转化生长因子-β1 激活调控 Madin-Darby 犬肾上皮细胞层粘连蛋白-332 的转录表达。
Mol Biol Cell. 2010 Nov 1;21(21):3654-68. doi: 10.1091/mbc.E10-06-0523. Epub 2010 Sep 15.
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Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.上皮细胞在 G2/M 期的细胞周期停滞介导损伤后的肾脏纤维化。
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Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.整合素介导的转化生长因子-β激活，纤维化疾病的一个潜在治疗靶点。
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9
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia.抑制自动调节的转化生长因子β信号传导可同时增强肾上皮细胞的增殖和分化，并促进肾缺血后的修复。
Am J Pathol. 2009 Apr;174(4):1291-308. doi: 10.2353/ajpath.2009.080295.
10
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).溶血磷脂酸通过LPA2受体和小G蛋白Gα(q)诱导αvβ6整合素介导的转化生长因子-β激活。
Am J Pathol. 2009 Apr;174(4):1264-79. doi: 10.2353/ajpath.2009.080160. Epub 2009 Jan 15.
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