光感受器中的纤毛信号级联反应。
Ciliary signaling cascades in photoreceptors.
作者信息
Yildiz Ozge, Khanna Hemant
机构信息
Department of Ophthalmology, UMASS Medical School, Worcester, MA 01605, USA.
出版信息
Vision Res. 2012 Dec 15;75:112-6. doi: 10.1016/j.visres.2012.08.007. Epub 2012 Aug 17.
Abstract
For being a polarized neuron and having a sensory cilium, photoreceptors attract remarkable attention. This is due their highly polarized structure and active visual signal transduction cascades and for the enrichment of complex networks of proteins in the cilium. Structural and functional maintenance of the photoreceptor sensory cilium, also called outer segment, ensures that light signal is received and relayed appropriately to the brain. Any perturbations in the protein content of the outer segment result in photoreceptor dysfunction, degeneration and eventually, blindness. This review focuses on the importance of photoreceptor sensory cilium to carry out signal transduction cascade for vision.
摘要
由于是极化神经元且具有感觉纤毛，光感受器备受关注。这是因为它们具有高度极化的结构、活跃的视觉信号转导级联反应以及纤毛中丰富的蛋白质复杂网络。光感受器感觉纤毛（也称为外段）的结构和功能维持确保光信号被接收并适当地传递到大脑。外段蛋白质含量的任何扰动都会导致光感受器功能障碍、退化，最终导致失明。本综述重点关注光感受器感觉纤毛在进行视觉信号转导级联反应中的重要性。
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