Department of Pathology, School of Medicine, New York University Cancer Institute, New York, NY 10016, USA.
J Cell Biol. 2011 May 2;193(3):435-44. doi: 10.1083/jcb.201101005.
The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase. Stringent regulations govern conversion between these two states. Although the molecular mechanisms have not been fully elucidated, recent findings have begun to shed light on pathways that regulate the conversion of centrioles to basal bodies and vice versa. Emerging studies also provide insights into how defects in the balance between centrosome and cilia function could promote ciliopathies and cancer.
中心粒的功能会随着细胞周期的变化而改变。在有丝分裂过程中，中心粒促进纺锤体极的形成，并作为基体组装间期的初级纤毛。严格的调控机制控制着这两种状态之间的转换。尽管分子机制尚未完全阐明，但最近的发现开始揭示调控中心粒向基体转化以及反之的途径。新兴的研究还提供了对中心体和纤毛功能之间平衡失调如何促进纤毛病和癌症的深入了解。
