Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Urology. 2012 Oct;80(4):780-3. doi: 10.1016/j.urology.2012.06.033. Epub 2012 Aug 22.
To examine the relationship between urine magnesium and hyperoxaluria in a cohort of patients with recurrent stone formation.
A total of 311 patients with nephrolithaisis were evaluated. The patients were divided into quintiles of urine magnesium excretion, an accepted surrogate of dietary magnesium intake. Multivariate analysis was used to examine the relationship between magnesium and hyperoxaluria.
The mean patient age was 50.0 ± 14.9 years, the body mass index was 28.0 ± 5.9 kg/m(2), and 130 were women and 181 were men. The mean urine magnesium excretion was 100.8 ± 42.0 mg/d (range 17.8-224.8). On multivariate analysis, an increasing quintile of urine magnesium was associated with decreasing hyperoxaluria (β = -0.37, 95% confidence interval -0.6 to -0.14, P < .05 for trend). When analyzed as separate quintiles with the lowest quintile of magnesium as the referent, only the greatest quintile demonstrated a statistically significant decrease in hyperoxaluria (β = -1.7, 95% confidence interval -2.7 to -0.7, P < .05 for trend).
Increasing magnesium intake was associated with decreasing hyperoxaluria in this population of patients with stone formation. Our findings showed that high magnesium intake might be required to observe clinically significant effects from magnesium.
在复发性结石形成患者队列中研究尿镁与高草酸尿之间的关系。
评估了 311 例肾结石患者。患者被分为五分位数的尿镁排泄量，这是饮食镁摄入量的公认替代指标。使用多变量分析来检查镁与高草酸尿之间的关系。
患者的平均年龄为 50.0 ± 14.9 岁，体重指数为 28.0 ± 5.9 kg/m²，其中女性 130 例，男性 181 例。尿镁排泄量的平均值为 100.8 ± 42.0 mg/d（范围 17.8-224.8）。多变量分析显示，尿镁五分位数的增加与高草酸尿的减少相关（β=-0.37，95%置信区间-0.6 至-0.14，趋势 P<.05）。当按五分位数分别分析时，以最低五分位数的镁为参考，只有最大五分位数的高草酸尿明显减少（β=-1.7，95%置信区间-2.7 至-0.7，趋势 P<.05）。
在该结石形成患者人群中，增加镁的摄入量与减少高草酸尿有关。我们的发现表明，可能需要高镁摄入量才能观察到镁的临床显著效果。
