Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Cytokine. 2012 Dec;60(3):767-71. doi: 10.1016/j.cyto.2012.07.034. Epub 2012 Aug 24.
Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte-endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (n=45)] and group C [those with higher risk of CAD (n=45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease.
细胞因子在冠状动脉疾病 (CAD) 的发病机制中起着极其重要的作用，其中白细胞介素 (IL)-7 是 T 细胞动态平衡的主要调节剂，可在炎症事件中刺激白细胞-内皮细胞黏附。循环中的 IL-7 与单核细胞和自然杀伤细胞的激活有关，导致在动脉粥样硬化和急性冠状动脉综合征中观察到的炎症细胞因子和趋化因子的产生增加。通过免疫酶联 ELISA 技术测量 IL-7、hs-CRP 和单核细胞趋化蛋白 (MCP)-1 的血浆水平。将 90 名神经病变性糖尿病足患者分为两组：B 组 [无 CAD（n=45）] 和 C 组 [CAD 风险较高（n=45）]。将 35 名健康受试者作为对照组（H 组）。与 H 组和 B 组相比，C 组的血浆 IL-7、MCP-1 和 hs-CRP 浓度明显升高。血浆 IL-7 水平与 hs-CRP 和 MCP-1 的血浆水平呈显著正相关。还观察到脂质谱异常。总之，本文观察到糖尿病足患者的血浆 IL-7、MCP-1 和 hs-CRP 浓度之间存在正相关，提示 IL-7 在促进冠心病临床不稳定方面可能发挥作用。
