Inonu University School of Medicine, Department of Ophthalmology, Malatya, Turkey.
Burns. 2013 Mar;39(2):326-30. doi: 10.1016/j.burns.2012.07.018. Epub 2012 Aug 24.
To evaluate the effects of resveratrol and bevacizumab on experimental corneal neovascularization.
A corneal alkali burn was performed in 62 eyes of 31 male white Vienna rabbits. Resveratrol (group 1), dimethyl sulfoxide (group 2), bevacizumab (group 3) and 0.9% NaCl (group 4) were administered to both eyes of the rabbits by subconjunctival injection for 7 days. Corneal photos were taken at 15 days after alkali injury. Inflammatory index scores and neovascularization areas were calculated.
In bevacizumab group both inflammatory index scores and the calculation of the corneal neovascularization area was significantly less than the groups.
The subconjunctival administration of bevacizumab inhibits corneal neovascularization effectively in the rabbit corneal alkali burn model. No effect of resveratrol to the corneal neovascularization on experimental model of the corneal alkali burn was seen at the doses of usage.
评估白藜芦醇和贝伐单抗对实验性角膜新生血管的作用。
对 31 只雄性白色维也纳兔的 62 只眼进行角膜碱烧伤。通过结膜下注射将白藜芦醇（第 1 组）、二甲基亚砜（第 2 组）、贝伐单抗（第 3 组）和 0.9%生理盐水（第 4 组）分别施用于兔子的双眼，持续 7 天。在碱烧伤后 15 天拍摄角膜照片。计算炎症指数评分和新生血管化区域。
贝伐单抗组的炎症指数评分和角膜新生血管化面积的计算均明显小于其他组。
贝伐单抗结膜下给药可有效抑制兔角膜碱烧伤模型中的角膜新生血管形成。在角膜碱烧伤实验模型中，未见白藜芦醇对角膜新生血管形成的作用。
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