Abu-Amero Khaled K, Kondkar Altaf A, Chalam Kakarla V
Department of Ophthalmology, University of Florida College of Medicine, FL 32209, USA.
Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11424, Saudi Arabia.
Nutrients. 2016 Apr 5;8(4):200. doi: 10.3390/nu8040200.
Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness. In vitro and in vivo (animal model) experimental studies performed so far have provided evidence for the biological effects of resveratrol on numerous pathways including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, pro-survival or angiogenesis that are implicated in the pathogenesis of these age-related ocular disorders. In this review, we provide a brief overview of current scientific literature on resveratrol, its plausible mechanism(s) of action, its potential use and current limitations as a nutritional therapeutic intervention in the eye and its related disorders.
白藜芦醇是一种存在于葡萄中的天然植物多酚，是红酒中的主要生物活性成分。临床研究表明，白藜芦醇因其强大的抗氧化和抗炎特性，具有心脏保护、化疗、神经保护作用，并显示出抗衰老效果。氧化应激和炎症在导致视力逐渐丧失和失明的与年龄相关的眼部疾病（青光眼、白内障、糖尿病视网膜病变和黄斑变性）的发生和发展中起关键作用。迄今为止进行的体外和体内（动物模型）实验研究为白藜芦醇对包括氧化应激、炎症、线粒体功能障碍、细胞凋亡、促生存或血管生成等众多途径的生物学效应提供了证据，这些途径与这些与年龄相关的眼部疾病的发病机制有关。在这篇综述中，我们简要概述了关于白藜芦醇的当前科学文献，其可能的作用机制，其作为眼部及其相关疾病的营养治疗干预措施的潜在用途和当前局限性。
