Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101318, China.
Cancer Lett. 2013 Jan 1;328(1):160-7. doi: 10.1016/j.canlet.2012.08.019. Epub 2012 Aug 23.
Cancer/testis antigens (CTAs) are highly immunogenic in many tumors, especially in non-small cell lung cancer (NSCLC). A low-density protein microarray, which consisted of 72 CTAs and six non-CTAs, was used to screen for lung cancer-related autoantibodies. The CTA panel of NY-ESO-1, XAGE-1, ADAM29 and MAGEC1, had sensitivity and specificity values of 33% and 96%, respectively. When examined in a test set, this panel of markers had sensitivity and specificity values of 36% and 89%, respectively. This array of markers preferentially detected NSCLC, but did not detect breast cancer, and non-cancer lung disease.
癌症/睾丸抗原（CTAs）在许多肿瘤中具有高度免疫原性，尤其是在非小细胞肺癌（NSCLC）中。使用包含 72 个 CTA 和 6 个非 CTA 的低密度蛋白质微阵列来筛选肺癌相关自身抗体。NY-ESO-1、XAGE-1、ADAM29 和 MAGEC1 的 CTA 组合的灵敏度和特异性值分别为 33%和 96%。在测试集中进行检查时，该标志物组合的灵敏度和特异性值分别为 36%和 89%。该标记物阵列优先检测 NSCLC，但未检测到乳腺癌和非癌症肺部疾病。
