Pańczyszyn Anna, Wieczorek Maciej
Samodzielna Katedra Biotechnologii i Biologii Molekularnej, Uniwersytet Opolski, Opole.
Postepy Hig Med Dosw (Online). 2012 Aug 24;66:574-82. doi: 10.5604/17322693.1008194.
Neutrophils express many surface adhesion molecules, including CEACAM1, CEACAM3, CEACAM4, CEACAM6 and CEACAM8 glycoproteins, which play an important role in biological functions of neutrophils such as adhesion, phagocytosis, oxidative burst and degranulation. CEACAM3 activates neutrophils and initiates phagocytosis as a result of binding to bacterial Opa protein. In addition, CEACAM1 and CEACAM6 can delay apoptosis. All neutrophil CEACAMs, except for CEACAM3, can stimulate adhesion of neutrophils to endothelium. One CEACAM family member, CEA, which is not expressed by neutrophils, displays strong chemotactic activity, and probably can prime and/or activate neutrophils to adhesion. Induction of CEACAM signaling can be initiated by dimerization of CEACAMs and/or phosphorylation of their cytoplasmic domains. CEACAM signaling is often associated with an increase in the cytoplasmic calcium level.
中性粒细胞表达多种表面黏附分子，包括癌胚抗原相关细胞黏附分子1（CEACAM1）、CEACAM3、CEACAM4、CEACAM6和CEACAM8糖蛋白，它们在中性粒细胞的生物学功能如黏附、吞噬作用、氧化爆发和脱颗粒中发挥重要作用。CEACAM3激活中性粒细胞并通过与细菌Opa蛋白结合引发吞噬作用。此外，CEACAM1和CEACAM6可延迟细胞凋亡。除CEACAM3外，所有中性粒细胞CEACAMs均可刺激中性粒细胞与内皮细胞的黏附。癌胚抗原相关细胞黏附分子家族成员之一癌胚抗原（CEA），中性粒细胞不表达，具有很强的趋化活性，可能能启动和/或激活中性粒细胞黏附。CEACAM信号的诱导可通过CEACAMs的二聚化和/或其胞质结构域的磷酸化启动。CEACAM信号通常与细胞质钙水平的升高有关。
