2010-2011 年度流行季，在西伯利亚西部分离的甲型 H3N2 流感病毒株的分子遗传学分析。

Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010-2011 epidemic season.

机构信息

State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk 630559, Russia.

出版信息

Infect Genet Evol. 2012 Dec;12(8):1694-8. doi: 10.1016/j.meegid.2012.07.014. Epub 2012 Aug 16.

DOI:10.1016/j.meegid.2012.07.014

Abstract

Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.

摘要

2011 年在西伯利亚西部分离的甲型 H3N2 流感病毒株的分子遗传和抗原特征与疫苗株 A/Perth/16/2009 相似，尽管存在一些独特的氨基酸变化。这些毒株在 NA 蛋白中缺乏特定的氨基酸变化，这降低了对在医学实践中使用的 NA 抑制剂活性的敏感性。基于 HA 蛋白氨基酸序列的系统发育分析，所研究的毒株与目前在欧亚大陆流行的甲型 H3N2 流感病毒株相似。