Teagasc Food Research Centre; Moorepark, Cork, Ireland.
Bioengineered. 2012 Nov-Dec;3(6):313-9. doi: 10.4161/bioe.21601. Epub 2012 Aug 24.
While the bacteriocin Nisin has been employed by the food industry for 60 y, it remains the only bacteriocin to be extensively employed as a food preservative. This is despite the fact that the activity of Nisin against several food spoilage and pathogenic bacteria is poor and the availability of many other bacteriocins with significant potential in this regard. An alternative route to address the deficiencies of Nisin is the application of bioengineered derivatives of the peptide which, despite differing only subtly, possess enhanced capabilities of commercial value. The career path which has taken me from learning for the first time what bacteriocins are to understanding the potential of bacteriocin bioengineering has been a hugely enjoyable experience and promises to get even more interesting in the years to come.
尽管细菌素尼生素已在食品工业中使用了 60 年，但它仍然是唯一被广泛用作食品防腐剂的细菌素。尽管尼生素对几种食品腐败菌和病原菌的活性较差，而且还有许多其他具有重要潜力的细菌素可用于这方面。解决尼生素缺陷的另一种方法是应用该肽的生物工程衍生产品，尽管这些衍生产品只有细微的差异，但具有增强的商业价值。从第一次学习细菌素是什么到了解细菌素生物工程的潜力，我的职业生涯一直是一段非常愉快的经历，而且在未来几年里，它还会变得更加有趣。
