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Catecholamine and cyclic nucleotide response of sheep to the injection of Clostridium welchii type D epsilon toxin.

作者信息

Worthington R W, Bertschinger H J, Mülders M S

出版信息

J Med Microbiol. 1979 Nov;12(4):497-501. doi: 10.1099/00222615-12-4-497.

DOI:10.1099/00222615-12-4-497
PMID:229224
Abstract

Injection of Clostridium welchii (C. perfringens) type D epsilon toxin into sheep caused large increases in catecholamine and cyclic adenosine 3',5'-monophosphate levels and moderate increases in cyclic guanosine 3',5'-monophosphate levels. Haemoconcentration also occurred. It is suggested that a rapidly developing brain oedema is the stimulus for a release of catecholamines which in turn activates adenyl cyclase. The resulting rise in cAMP causes glycogenolysis and hyperglycaemia.

摘要

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