Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
J Biochem. 2012 Oct;152(4):313-9. doi: 10.1093/jb/mvs092. Epub 2012 Aug 24.
Acute inflammation is an indispensable host response to foreign challenges or tissue injury. In healthy conditions, inflammatory processes are self-limiting and self-resolving, suggesting the existence of endogenous mechanisms for the control of inflammation and resolution. A comprehensive understanding of the cellular and molecular events of a well-orchestrated inflammatory response is required, and recent studies have uncovered the roles of endogenous lipid mediators derived from polyunsaturated fatty acids (i.e. lipoxins, resolvins, protectins) in controlling the resolution of inflammation. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and the emerging roles of eosinophils and eosinophil-derived lipid mediators in controlling acute inflammation and resolution.
急性炎症是宿主对外来挑战或组织损伤的必不可少的反应。在健康条件下，炎症过程是自我限制和自我解决的，这表明存在控制炎症和消退的内源性机制。需要全面了解精心协调的炎症反应的细胞和分子事件，最近的研究揭示了内源性脂质介质（即脂氧素、解析素、保护素）衍生自多不饱和脂肪酸在控制炎症消退中的作用。本综述介绍了对这些介质的形成和作用的最新理解，特别是重点介绍了基于 LC-MS/MS 的脂质组学方法以及嗜酸性粒细胞和嗜酸性粒细胞衍生的脂质介质在控制急性炎症和消退中的新兴作用。
