Ariel Amiram, Serhan Charles N
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Trends Immunol. 2007 Apr;28(4):176-83. doi: 10.1016/j.it.2007.02.007. Epub 2007 Mar 6.
The physiological resolution of a well-orchestrated inflammatory response is essential to maintain homeostasis. Therefore, gaining a comprehensive understanding in molecular terms of the events that direct the termination of acute inflammation is imperative. Recently, new families of local-acting mediators were discovered that are biosynthesized from the essential fatty acids eicosapentaenoic acid and docosahexaenoic acid. These new chemical mediators are endogenously generated in inflammatory exudates collected during the resolution phase, and were termed resolvins and protectins because specific members of these families control the magnitude and duration of inflammation in animals. In addition, recent results indicate novel actions of resolvins and protectins in removing chemokines ferried from the tissue by apoptotic neutrophils and T cells during resolution. Here, we review recent advances on the biosynthesis and actions of these novel anti-inflammatory and proresolving mediators.
精心编排的炎症反应的生理消退对于维持体内平衡至关重要。因此，从分子层面全面了解指导急性炎症终止的事件势在必行。最近，发现了新的局部作用介质家族，它们由必需脂肪酸二十碳五烯酸和二十二碳六烯酸生物合成。这些新的化学介质在消退期收集的炎性渗出物中内源性产生，由于这些家族的特定成员控制动物炎症的程度和持续时间，因此被称为消退素和保护素。此外，最近的结果表明，在消退过程中，消退素和保护素在清除由凋亡中性粒细胞和T细胞从组织中运送的趋化因子方面具有新作用。在此，我们综述了这些新型抗炎和促消退介质在生物合成和作用方面的最新进展。
