两株对人横纹肌肉瘤细胞具有细胞毒性的柯萨奇病毒 A1 株的全基因组序列。
Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells.
机构信息
WHO WPRO Regional Polio Reference Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
出版信息
J Virol. 2012 Sep;86(18):10228-9. doi: 10.1128/JVI.01567-12.
Abstract
Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events occurred between CVA1 and CVA22.
摘要
柯萨奇病毒 A1 （CVA1）属于小核糖核酸病毒科肠道病毒 C 种，小RNA 病毒目。中国的两个 CVA1 分离株 HT-THLH02F/XJ/CHN/2011 和 KS-ZPH01F/XJ/CHN/2011 是从中国新疆维吾尔自治区的两个健康儿童的粪便标本中分离出来的。它们在人横纹肌肉瘤细胞系中引起细胞病变效应，这两个 CVA1 分离株的完整基因组序列表明，CVA1 和 CVA22 之间发生了自然的型间重组事件。
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