Complete genome analysis of coxsackievirus A24 isolated in Yunnan, China, in 2013.

作者信息

Zhao Yilin, Liu Jiansheng, Zhang Haihao, Guo Chen, Xia Longhui, Yang Fang, Yang Huai, Yang Qinxing, Yang Zhaoqing, Ma Shaohui

机构信息

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS and PUMC), 935 Jiao Ling Road, Kunming, 650118, Yunnan, People's Republic of China.

Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, 650118, People's Republic of China.

出版信息

Arch Virol. 2016 Jun;161(6):1705-9. doi: 10.1007/s00705-016-2792-0. Epub 2016 Mar 3.

Human coxsackievirus A24 (CVA24) belongs to the species Enterovirus C, and variants of this virus frequently cause acute hemorrhagic conjunctivitis (AHC). The complete genome of the K282/YN/CHN/2013 strain, isolated from a healthy child in Yunnan, China, in 2013, is reported here for the first time. The strain showed 80.0 % and 79.9 % nucleotide sequence identity to CVA24 prototype strain Joseph and CVA24 variant prototype EH24, respectively. The K282/YN/CHN/2013 strain belongs to the CVA24 serotype. Twelve amino acid differences, most of which are in structural regions, were found between the CVA24 and CVA24v strains. In the whole-length genome sequence, only the structural region of K282/YN/CHN/2013 was similar to that of the CVA24 strains; the other genome regions were more similar to those of other members of the species Enterovirus C. Recombination analysis showed evidence of recombination with other viruses of the same species.