Torres-Mora Jorge, Moyer Ann, Topazian Mark, Alexander Jeffrey, Wu Tsung-Teh, Seys Amber, Fritchie Karen
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Case Rep Gastrointest Med. 2012;2012:141693. doi: 10.1155/2012/141693. Epub 2012 Aug 14.
Liposarcoma is one of the most common sarcomas in adults, but only rarely presents as an esophageal primary. There have been several reports of well-differentiated liposarcoma (WDL) arising in the esophagus, but we present a case of dedifferentiated liposarcoma (DL) presenting as a large esophageal polyp. We believe this is the first reported case of DL of the esophagus with morphologic evidence of both well-differentiated and dedifferentiated components. The diagnosis was confirmed by demonstration of CPM gene amplification by fluorescence in situ hybridization (FISH).
脂肪肉瘤是成人中最常见的肉瘤之一，但极少以食管原发性肿瘤的形式出现。已有数篇关于食管中发生的高分化脂肪肉瘤（WDL）的报道，但我们报告了一例以巨大食管息肉形式出现的去分化脂肪肉瘤（DL）。我们认为这是首例有形态学证据显示同时存在高分化和去分化成分的食管去分化脂肪肉瘤病例。通过荧光原位杂交（FISH）证实CPM基因扩增从而确诊。
