胃食管交界部去分化脂肪肉瘤
Dedifferentiated Liposarcoma of the Gastroesophageal Junction.
作者信息
Aşkan Gökçe, Bağci Pelin, Hameed Meera, Baştürk Olca
机构信息
Departments of Pathology, Marmara University Faculty of Medicine, İSTANBUL, TURKEY.
出版信息
Turk Patoloji Derg. 2018;34(1):104-107. doi: 10.5146/tjpath.2014.01297.
Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.
脂肪肉瘤是成人中最常见的肉瘤之一，但极少以原发性肿瘤的形式出现在上消化道系统。在此，我们报告一名71岁男性患者，该患者先后接受了两次楔形切除活检，随后因复发性胃食管交界肿物接受了细针穿刺活检和全胃切除术。在显微镜切片中，可见高分化和去分化成分。肿瘤细胞MDM2、CDK4呈阳性，CD117、DOG1、CD34、SMA、结蛋白、S-100、HMB45、SOX10、AE1/AE3、CAM5.2、CK18呈阴性。进行了荧光原位杂交（FISH）检测，发现MDM2基因（12q15）扩增。根据这些发现，支持去分化脂肪肉瘤的诊断。我们认为这是首例报道的胃食管交界去分化脂肪肉瘤病例。
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