Hentova-Senćanić Paraskeva P, Bozić Marija M, Senćanić Ivan M, Stojcić Milan M, Stanković Branislav R, Marković Vujica D, Marjanović Ivan S, Babić Vesna D
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Acta Chir Iugosl. 2012;59(1):61-6.
To compare the mean intraocular pressure (IOP), peak IOP and percentage reduction in IOP in the first five years following trabeculectomy between the patients with progressed visual field loss and the patients with stable visual fields.
Thirty-six eyes of 36 patients were followed for five years after their first trabeculectomy with tonometry and automated perimetry (Octopus 500EZ, program G1). The rate of change of the visual field was measured by linear regression analysis of the mean sensitivity value (dB) of each field test versus time (month). Based on the statistical significance of the slope of the regression line (Spearman p value of the correlation coefficient less than 0.05), patients were divided into two groups: with significant negative slope of the regression line (group with progressed visual field loss) and with non-significant slope of the regression line (group with stable visual field). The mean IOP values and percentage of IOP reduction at the end of each of the first five years after surgery were compared between the group with progressed field loss and group with stable fields by using Mann-Whitney U test.
Patients with progressed visual field loss had higher mean IOP, higher peak IOP and less reduction in pressure after the operation than patients with stable visual field. The mean IOP at end of the two year postoperative period was significantly higher in patients with progressed visual field loss (21.98 +/- 3.38 mmHg) than in those with stable fields (17.48 +/- 4.80 mmHg). The mean percentage reduction in IOP at the end of two year postoperative period was significantly less in patients that showed progression of field loss (21.84%) than in those with stable fields (41.0%).
Prognosis for further field loss seems to be better if postoperative pressure is at lower levels and greater percent reduction of IOP is obtained after surgery. The data that predict better prognosis is the mean postoperative IOP value of approximately 18 mmHg or less resulting from at least 35% of IOP reduction.
比较视野进展性丧失患者与视野稳定患者小梁切除术后头五年的平均眼压（IOP）、眼压峰值及眼压降低百分比。
对36例患者的36只眼在首次小梁切除术后进行了五年的随访，采用眼压测量法和自动视野计（Octopus 500EZ，程序G1）。通过对每次视野检查的平均敏感度值（dB）与时间（月）进行线性回归分析来测量视野的变化率。根据回归线斜率的统计学显著性（相关系数的Spearman p值小于0.05），将患者分为两组：回归线斜率显著为负的组（视野进展性丧失组）和回归线斜率无显著性的组（视野稳定组）。采用Mann-Whitney U检验比较视野进展性丧失组和视野稳定组术后头五年每年末的平均眼压值及眼压降低百分比。
与视野稳定的患者相比，视野进展性丧失的患者平均眼压更高、眼压峰值更高且术后眼压降低幅度更小。术后两年末，视野进展性丧失患者的平均眼压（21.98±3.38 mmHg）显著高于视野稳定患者（17.48±4.80 mmHg）。视野丧失进展的患者术后两年末眼压降低的平均百分比（21.84%）显著低于视野稳定的患者（41.0%）。
如果术后眼压处于较低水平且术后眼压降低百分比更大，则进一步视野丧失的预后似乎更好。预测预后较好的数据是术后平均眼压值约为18 mmHg或更低，且眼压降低至少35%。
