Cheng Wei, Zhu Cheng-Gen, Xu Wen-Dong, Fan Xiao-Na, Yang Yong-Chun, Li Yan, Shi Jian-Gong
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2012;14(11):1046-53. doi: 10.1080/10286020.2012.702762. Epub 2012 Aug 28.
Five new phenylpropene diglycosides (1-5), together with three known analogs, have been isolated from an ethanol extract of the bark of Machilus wangchiana. Their structures were determined by spectroscopic and chemical methods. In the preliminary assay, compounds 2 and 5-8 reduced dl-galactosamine (GalN)-induced hepatocyte (WB-F344 cells) damage with 37-41% inhibitions at 10 μM.
从黄枝润楠树皮的乙醇提取物中分离得到了5个新的苯丙烯二糖苷（1-5）以及3个已知类似物。通过光谱和化学方法确定了它们的结构。在初步试验中，化合物2和5-8可减轻dl-半乳糖胺（GalN）诱导的肝细胞（WB-F344细胞）损伤，在10 μM浓度下抑制率为37-41%。
