Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
J Nat Prod. 2010 Feb 26;73(2):177-84. doi: 10.1021/np900593q.
Eleven new diglycosides, erycibosides A-K (1-11), four new chlorogenic acid derivatives (14-17), and a new bis-coumarin (18), together with 21 known compounds, have been isolated from an EtOH extract of the roots and stems of Erycibe hainanesis. Their structures were elucidated by means of spectroscopic methods and chemical evidence. Inhibitory activities of some of the compounds on d-galactosamine-induced cytotoxicity in WB-F344 rat hepatic epithelial stem-like cells were screened, and compounds 2, 6, 10, 18, and 32 showed potent hepatoprotective activities at concentrations of 1 x 10(-5) to 1 x 10(-4) M.
从海南蛇菰的根和茎的乙醇提取物中分离得到了 11 个新的二糖苷，erycibosides A-K（1-11），4 个新的绿原酸衍生物（14-17）和一个新的双香豆素（18），以及 21 个已知化合物。通过光谱方法和化学证据阐明了它们的结构。筛选了一些化合物对 d-半乳糖胺诱导的 WB-F344 大鼠肝上皮干细胞样细胞毒性的抑制活性，化合物 2、6、10、18 和 32 在 1x10(-5)至 1x10(-4)M 的浓度下表现出很强的保肝活性。
