DNA高甲基化促进与慢性髓性白血病BCR-ABL1融合基因相关的促凋亡基因BCL2L11低表达。 - Suppr

Suppr

超能文献

DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR-ABL1 fusion gene of chronic myeloid leukaemia.

作者信息

Leo Elisa, Mancini Manuela, Aluigi Michela, Castagnetti Fausto, Martinelli Giovanni, Barbieri Enza, Santucci Maria A

出版信息

Br J Haematol. 2012 Nov;159(3):373-6. doi: 10.1111/bjh.12023. Epub 2012 Aug 25.

DOI:10.1111/bjh.12023

PMID:22924699

Abstract

摘要

相似文献

DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR-ABL1 fusion gene of chronic myeloid leukaemia.DNA高甲基化促进与慢性髓性白血病BCR-ABL1融合基因相关的促凋亡基因BCL2L11低表达。

Br J Haematol. 2012 Nov;159(3):373-6. doi: 10.1111/bjh.12023. Epub 2012 Aug 25.

DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia.DNA甲基转移酶1驱动与慢性髓性白血病BCR-ABL1基因相关的β-连环蛋白拮抗剂Chibby1的转录下调。

J Cell Biochem. 2015 Apr;116(4):589-97. doi: 10.1002/jcb.25010.

Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.BIM表达的表观遗传下调与慢性髓性白血病对伊马替尼治疗的最佳反应降低有关。

Eur J Cancer. 2009 Jul;45(10):1877-89. doi: 10.1016/j.ejca.2009.04.005. Epub 2009 May 4.

The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells.促凋亡基因BID和BIM的表观遗传修饰在伊马替尼耐药慢性髓性白血病细胞中的作用

Hematology. 2013 Jul;18(4):217-23. doi: 10.1179/1607845412Y.0000000056. Epub 2013 Jan 25.

ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance.由BCR-ABL调节的凋亡微小RNA表达与慢性粒细胞白血病进展及伊马替尼耐药相关。

Blood Cells Mol Dis. 2014 Jun-Aug;53(1-2):47-55. doi: 10.1016/j.bcmd.2014.02.008. Epub 2014 Mar 11.

The BCL2L11 (BIM) deletion polymorphism is a possible criterion for discontinuation of imatinib in chronic myeloid leukaemia patients.BCL2L11（BIM）缺失多态性可能是慢性髓性白血病患者停用伊马替尼的一个标准。

Br J Haematol. 2013 Jan;160(2):269-71. doi: 10.1111/bjh.12111. Epub 2012 Nov 1.

Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells.BCR/ABL1对威尔姆斯瘤基因1蛋白（WT1）的去调控介导了人白血病细胞对伊马替尼的耐药性。

Leukemia. 2007 Dec;21(12):2485-94. doi: 10.1038/sj.leu.2404924. Epub 2007 Aug 30.

Cleavage of BCR-ABL transcripts at the T315I point mutation by DNAzyme promotes apoptotic cell death in imatinib-resistant BCR-ABL leukemic cells.DNA 酶在 T315I 点突变处切割 BCR-ABL 转录本，促进伊马替尼耐药 BCR-ABL 白血病细胞的凋亡性细胞死亡。

Leukemia. 2013 Aug;27(8):1650-8. doi: 10.1038/leu.2013.60. Epub 2013 Feb 25.

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene.BCR/ABL1和BCR受MYC癌基因的转录调控。

Mol Cancer. 2015 Jul 16;14:132. doi: 10.1186/s12943-015-0407-0.

Monocyte-derived dendritic cells from chronic myeloid leukaemia have abnormal maturation and cytoskeletal function that is associated with defective localisation and signalling by normal ABL1 protein.慢性髓系白血病患者的单核细胞衍生树突状细胞存在异常成熟和细胞骨架功能，这与正常ABL1蛋白的定位缺陷和信号传导有关。

Eur J Haematol. 2014 Aug;93(2):96-102. doi: 10.1111/ejh.12306. Epub 2014 Apr 10.

引用本文的文献

Single-walled and multi-walled carbon nanotubes induce sequence-specific epigenetic alterations in 16 HBE cells.单壁和多壁碳纳米管在16HBE细胞中诱导序列特异性表观遗传改变。

Oncotarget. 2018 Apr 17;9(29):20351-20365. doi: 10.18632/oncotarget.24866.

and methylation in male laryngeal cancer patients.以及男性喉癌患者的甲基化情况。

Oncol Lett. 2016 Oct;12(4):2999-3003. doi: 10.3892/ol.2016.5018. Epub 2016 Aug 16.

Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence.头颈部鳞状细胞癌生存与复发的基因表达分析

Oncotarget. 2015 Jan 1;6(1):547-55. doi: 10.18632/oncotarget.2772.

BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia.慢性髓性白血病中BCR-ABL1相关的β-连环蛋白拮抗剂Chibby1的减少

PLoS One. 2013 Dec 10;8(12):e81425. doi: 10.1371/journal.pone.0081425. eCollection 2013.

Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.通过 MeCP2/SIN3a 去乙酰化复合物，使促凋亡基因 BIM 在间变大细胞淋巴瘤中发生表观遗传沉默。

Neoplasia. 2013 May;15(5):511-22. doi: 10.1593/neo.121784.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验