Department of Radiation Oncology, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.
Clin Otolaryngol. 2012 Oct;37(5):369-75. doi: 10.1111/coa.12010.
To explore the possible association between the risk of coronary artery disease and head or neck cancer based on some possible shared risk factors and/or treatment-related complications.
A population-based retrospective cohort study.
All new 729 patients with head and neck cancer diagnosed between 2000 and 2003 were followed up till 2009, and the risk of subsequent coronary artery disease was calculated. For each patient, the risk was calculated in 4 age-and sex-matched population controls. Matching was not possible for factors including socio-economic group and smoking.
Cox's proportional hazard regression analysis was conducted to estimate the relationship between head or neck cancer and risk of coronary artery disease.
For patients with head or neck cancer, the overall risk for developing coronary artery disease was almost the same as that of the control group [adjusted hazard ratio (but without control for some lifestyle factors): 0.95; 95% confidence interval: 0.65-1.35]. Overall, we found no increased risk of coronary artery disease for patients with head or neck cancer when the data were categorised either by treatment methods or by cancer subsites.
This population-based study indicated that patients with head or neck cancer were at no higher risk of developing coronary artery disease than was the general population over a 6- to 9-year period; however, we cannot exclude the risk over a longer period of time.
基于一些可能的共同危险因素和/或治疗相关并发症，探讨头颈部癌症与冠心病发病风险之间的可能关联。
基于人群的回顾性队列研究。
所有新诊断的 729 例头颈部癌症患者（2000 年至 2003 年），随访至 2009 年，计算随后发生冠心病的风险。为每位患者计算了 4 名年龄和性别匹配的人群对照者的风险。包括社会经济群体和吸烟在内的因素无法进行匹配。
采用 Cox 比例风险回归分析来估计头颈部癌症与冠心病发病风险之间的关系。
对于头颈部癌症患者，发生冠心病的总体风险与对照组相似[调整后的危险比（未控制一些生活方式因素）：0.95；95%置信区间：0.65-1.35]。总体而言，无论按治疗方法还是癌症亚部位分类，我们都没有发现头颈部癌症患者发生冠心病的风险增加。
本基于人群的研究表明，在 6 至 9 年的时间内，头颈部癌症患者发生冠心病的风险并不高于一般人群；然而，我们不能排除更长时间内的风险。
