Kanda Eriko, Yamaguchi Koushi, Hanaoka Masachi, Matsui Hideo, Sago Haruhiko, Kubo Takahiko
Center for Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
J Obstet Gynaecol Res. 2013 Feb;39(2):500-3. doi: 10.1111/j.1447-0756.2012.01997.x. Epub 2012 Aug 26.
Measles during pregnancy has deleterious effects on both perinatal and maternal outcomes. In Japan, local epidemics of measles and cases of measles during pregnancy are still being reported; therefore, the seroprevalence of antibodies to measles is suspected to be still not sufficient. The aim of this study was to analyze the seroprevalence of antibodies to measles in Japanese pregnant women and estimate the percentage of these women who require vaccination or revaccination against measles.
We analyzed the seroprevalence of immunity to measles by the neutralization test in 10 349 pregnant women in the first trimester managed at the National Center for Child Health and Development between February 2004 and December 2010. The neutralization test titers were interpreted as follows: ≧1:8, seropositive; =4, low-positive; ≦4, seronegative.
Of the total number of pregnant women tested, 7408 (71.6%) were seropositive, 1864 (18.0%) were low-positive, and 1079 (10.4%) were seronegative for measles antibodies, respectively.
Our results revealed that 28% of our pregnant population was seronegative or low-positive for measles antibodies, and thought to require revaccination or vaccination. Screening for measles immunity might be advisable for women of childbearing age.
孕期麻疹会对围产期及孕产妇结局产生有害影响。在日本，仍有麻疹局部流行及孕期麻疹病例的报告；因此，怀疑麻疹抗体的血清阳性率仍不充足。本研究的目的是分析日本孕妇中麻疹抗体的血清阳性率，并估算这些需要接种或再次接种麻疹疫苗的女性比例。
我们对2004年2月至2010年12月期间在国立儿童健康与发展中心接受管理的10349名孕早期孕妇，通过中和试验分析了麻疹免疫的血清阳性率。中和试验滴度的解读如下：≧1:8，血清阳性；=4，低阳性；≦4，血清阴性。
在接受检测的孕妇总数中，麻疹抗体血清阳性者有7408人（71.6%），低阳性者有1864人（18.0%），血清阴性者有1079人（10.4%）。
我们的结果显示，28%的孕妇麻疹抗体呈血清阴性或低阳性，被认为需要再次接种或接种疫苗。对育龄女性进行麻疹免疫筛查可能是可取的。
