Al-Khateeb Alyaa, Mohamed Mohd Sapawi, Imran Kamarul, Ibrahim Suhairi, Zilfalil Bin Alwi, Yusof Zurkurnai
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Kobe J Med Sci. 2011 Dec 15;57(2):E38-48.
The importance of serum lipids as cardiovascular risk factors is well recognized. However, most published studies have focused on western countries. The present study aimed to describe and analyze the lipid profile parameters in Malaysian dyslipidemic patients, and to identify concomitant clinical problems and risk factors associated with cardiovascular disease (CVD) among such patients.
A retrospective record review was carried out at Hospital Universiti Sains Malaysia. The records were reviewed for 890 dyslipidemic patients who attended the hospital in 2007. Data were collected for age at time of presentation, sex, ethnicity, smoking status, pre-treatment lipid levels, and presence of associated illnesses. The study sample was classified according to the National Cholesterol Education Program Adult Treatment Panel III risk groups.
The mean (SD) values for total cholesterol, low-density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglycerides were 6.4 (1.3), 4.1 (1.3), 1.4 (0.5) and 1.9 (1.2) mmol/l, respectively. Less than half of study sample (43.1%) had coronary heart disease and coronary heart diseases equivalents, 24.3% were at moderate risk, and 32.6% were at low risk. Hypertension was present in 79.9% of the study sample, while 27.5% were diabetics. Cardiovascular disease was reported among 17.9%. Logistic regression revealed that family history of premature cardiovascular disease, higher age risk group; ethnicity and total cholesterol were predictors for the development of cardiovascular disease.
The present review showed that dyslipidemic patients had high total cholesterol levels, according to National Cholesterol Education Program Adult Treatment Panel III guidelines. They were clinically diagnosed at middle age. Hypertension and diabetes were the commonest associated clinical problems. A large proportion of the patients were within the coronary heart disease or coronary heart disease risk equivalent group. Family history of premature cardiovascular disease, age, ethnicity, and total cholesterol are important risk factors for the development of cardiovascular disease in Malaysian dyslipidemic patients.
血清脂质作为心血管危险因素的重要性已得到充分认识。然而，大多数已发表的研究都集中在西方国家。本研究旨在描述和分析马来西亚血脂异常患者的血脂谱参数，并确定这些患者中与心血管疾病（CVD）相关的伴随临床问题和危险因素。
在马来西亚理科大学医院进行了一项回顾性记录审查。对2007年到该医院就诊的890名血脂异常患者的记录进行了审查。收集了就诊时的年龄、性别、种族、吸烟状况、治疗前血脂水平以及相关疾病的存在情况等数据。研究样本根据美国国家胆固醇教育计划成人治疗小组第三次报告的风险组进行分类。
总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的平均（标准差）值分别为6.4（1.3）、4.1（1.3）、1.4（0.5）和1.9（1.2）mmol/l。不到一半的研究样本（43.1%）患有冠心病和冠心病等同症，24.3%处于中度风险，32.6%处于低风险。79.9%的研究样本患有高血压，27.5%为糖尿病患者。报告有心血管疾病的占17.9%。逻辑回归显示，心血管疾病早发家族史、年龄风险组较高、种族和总胆固醇是心血管疾病发生的预测因素。
本综述表明，根据美国国家胆固醇教育计划成人治疗小组第三次报告的指南，血脂异常患者的总胆固醇水平较高。他们在中年时被临床诊断。高血压和糖尿病是最常见的相关临床问题。很大一部分患者属于冠心病或冠心病风险等同组。心血管疾病早发家族史、年龄、种族和总胆固醇是马来西亚血脂异常患者发生心血管疾病的重要危险因素。
