Center for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore.
J Pain Symptom Manage. 2013 Apr;45(4):782-91. doi: 10.1016/j.jpainsymman.2012.03.012. Epub 2012 Aug 25.
The Functional Assessment of Cancer Therapy--Breast Symptom Index (FBSI) is an eight-item instrument extracted from the Functional Assessment of Cancer Therapy--Breast (FACT-B). There has been no formal assessment of this eight-item version.
This study aimed to examine the measurement properties of and comparability between the English and the Chinese versions of the FBSI and to compare it with its parent instrument, the FACT-B, in breast cancer patients in Singapore.
This was an observational study of 271 breast cancer patients. Known-group validity of FBSI scores was assessed using four health indicators. Convergent and divergent validity was examined by correlation coefficients between the FBSI and the FACT-B. Responsiveness was assessed in relation to longitudinal changes in performance status. Test-retest reliability was evaluated by the intraclass correlation coefficient. Multiple regression analyses were performed to compare the scores on the two language versions. Receiver operating characteristic curve analyses were used for comparison between the FBSI and the FACT-B.
For both language versions, the FBSI demonstrated known-group validity, convergent and divergent validity, and sufficient test-retest reliability (intraclass correlation coefficient = 0.75-0.77). The English version was responsive to changes in performance status. The Chinese version was responsive to decline in performance status, but there was no conclusive evidence about its responsiveness to improvement in performance status. No practical significant difference was found in the outcomes between the two language versions despite minor difference in one item. The FBSI performed comparably with the FACT-B.
The English and Chinese versions of the FBSI are valid and reliable and provide comparable FBSI scores. The English version is responsive to change, whereas the responsiveness of the Chinese version warrants further study.
癌症治疗功能评估-乳房症状指数（FBSI）是从癌症治疗功能评估-乳房（FACT-B）中提取的八项量表。尚未对这八项版本进行正式评估。
本研究旨在检验 FBSI 的英文版和中文版的测量特性和可比性，并在新加坡的乳腺癌患者中与母表 FACT-B 进行比较。
这是一项对 271 例乳腺癌患者的观察性研究。使用四个健康指标评估 FBSI 评分的已知组有效性。通过 FBSI 与 FACT-B 之间的相关系数来检验聚合和发散效度。通过与功能状态的纵向变化相关的反应性来评估反应性。通过组内相关系数评估测试-重测信度。进行多元回归分析比较两种语言版本的分数。通过接收者操作特征曲线分析比较 FBSI 和 FACT-B。
对于两种语言版本，FBSI 均表现出已知组有效性、聚合和发散效度以及足够的测试-重测信度（组内相关系数=0.75-0.77）。英文版对功能状态的变化有反应。中文版对功能状态的下降有反应，但对功能状态的改善没有明确的反应证据。尽管在一个项目上存在细微差异，但两种语言版本的结果之间没有发现实际的显著差异。FBSI 的表现与 FACT-B 相当。
FBSI 的英文版和中文版均有效且可靠，并提供可比的 FBSI 评分。英文版对变化有反应，而中文版的反应性需要进一步研究。
