Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH-3012 Bern, Switzerland.
Trends Immunol. 2012 Dec;33(12):579-89. doi: 10.1016/j.it.2012.07.004. Epub 2012 Aug 25.
The central nervous system (CNS) is an immunologically privileged site to which access of circulating immune cells is tightly controlled by the endothelial blood-brain barrier (BBB; see Glossary) localized in CNS microvessels, and the epithelial blood-cerebrospinal fluid barrier (BCSFB) within the choroid plexus. As a result of the specialized structure of the CNS barriers, immune cell entry into the CNS parenchyma involves two differently regulated steps: migration of immune cells across the BBB or BCSFB into the cerebrospinal fluid (CSF)-drained spaces of the CNS, followed by progression across the glia limitans into the CNS parenchyma. With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers.
中枢神经系统（CNS）是一个免疫特权部位，循环免疫细胞进入其中受到严格控制，这是由 CNS 微血管中的内皮血脑屏障（BBB；见词汇表）和脉络丛中的上皮血脑脊液屏障（BCSFB）来实现的。由于 CNS 屏障的特殊结构，免疫细胞进入 CNS 实质涉及两个不同调节的步骤：免疫细胞穿过 BBB 或 BCSFB 进入 CSF 引流的 CNS 空间，然后穿过胶质界膜进入 CNS 实质。本文聚焦多发性硬化症（MS）及其动物模型，总结了免疫细胞穿过不同 CNS 屏障所需的独特分子机制。
