Vaccine Evaluation Center, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Pediatr Infect Dis J. 2013 Jan;32(1):e20-5. doi: 10.1097/INF.0b013e3182706b89.
Invasive meningococcal disease remains a rare but deadly infection in Canada. New serogroup B vaccines may offer the potential for prevention and control. This report examines the disease burden caused by serogroup B invasive meningococcal infections.
From 2002 to 2011, active, population-based metropolitan area surveillance for adult and pediatric hospital admissions for adult and pediatric hospital admissions for laboratory-confirmed infection with Neisseria meningitidis, was conducted by the 12 centers of the Canadian Immunization Monitoring Program, Active.
A total of 769 invasive meningococcal cases occurred from 2002 to 2011; 54% (n = 413) in children with a peak incidence of 6.16 (95% confidence interval: 3.18-10.76) per 100,000 in children aged <1 year in 2009. Serogroup B accounted for the largest proportion of cases and had the highest incidence of all serogroups across all ages, with a peak incidence of 0.31 (0.23-0.40) per 100,000 in 2007. Serogroup B case fatality rate was 4.3% in children, and 21% of pediatric survivors had sequelae. B:17:P1.19 ST-269 was the most frequently detected antigenic type.
Serogroup B invasive meningococcal infections caused substantial morbidity and mortality and are the leading cause of invasive meningococcal disease in Canada. The proportion of cases potentially preventable with the new serogroup B vaccines should be evaluated to determine whether universal immunization programs are warranted.
侵袭性脑膜炎球菌病在加拿大仍然是一种罕见但致命的感染。新的 B 群脑膜炎球菌疫苗可能具有预防和控制的潜力。本报告研究了 B 群侵袭性脑膜炎球菌感染造成的疾病负担。
从 2002 年到 2011 年，加拿大免疫监测计划主动监测项目的 12 个中心对成人和儿科医院因实验室确诊的脑膜炎奈瑟菌感染而住院的成人和儿童进行了主动、基于人群的监测。
2002 年至 2011 年期间共发生 769 例侵袭性脑膜炎球菌病例；54%（n=413）发生在儿童中，2009 年<1 岁儿童发病率最高，为每 100,000 人 6.16（95%置信区间：3.18-10.76）。B 群血清型占病例的最大比例，在所有年龄组中发病率最高，所有血清型中发病率最高的为 0.31（0.23-0.40），发生在 2007 年。儿童的 B 群脑膜炎球菌病病死率为 4.3%，儿科幸存者中有 21%有后遗症。B:17:P1.19 ST-269 是最常检测到的抗原型。
B 群侵袭性脑膜炎球菌感染导致了大量的发病率和死亡率，是加拿大侵袭性脑膜炎球菌病的主要原因。应评估新的 B 群疫苗可预防的病例比例，以确定是否需要开展普遍免疫规划。
