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失牙、缺牙和补牙指数及白血病患儿长期生存者的牙体畸形:一项前瞻性对照研究。

Decayed, missing and filled teeth index and dental anomalies in long-term survivors leukaemic children: a prospective controlled study.

机构信息

Department of Neuroscience University of Milano - Bicocca - Italy

出版信息

Med Oral Patol Oral Cir Bucal. 2012 Nov 1;17(6):e977-80. doi: 10.4317/medoral.17955.

Abstract

OBJECTIVE

The aim of this prospective controlled study is the comparison between long-term children survived leukaemia and a control group in terms of the decayed, missing or filled permanent teeth (DMFT) and dental anomalies.

STUDY DESIGN

Fifty-two long term children survived leukaemia, aged from 8 to 15 years (27 females, 25 males; mean age 11.5 years) were evaluated for the possible effects of the anti-leukaemic therapy on dental development and compared to a control group of 52 healthy children (27 females, 25 males, mean age 11 years). All long-term children who survived were at least 24 months in continuous complete remission. The study of the dental status with a routine oral examination and panoramic radiographs was performed. The DMFT (recorded according to the WHO criteria) and dental anomalies were registered and evaluated.

RESULTS

The results of this study evidence that long-term children survived leukaemia, in comparison with the control group, have an higher risk to develop dental caries and show a greater severity of dental anomalies including V-shaped roots, dental agenesis, microdontia, enamel dysplasias.

CONCLUSIONS

Paediatric patients with haemathological diseases require a special attentions in dental care in addition to the antineoplastic treatment. Therefore, oral hygiene and oral health can be maintained thanks to a close cooperation between the paediatric oncohaematologists, pediatrics dental surgeons and dental hygienists.

摘要

目的

本前瞻性对照研究旨在比较长期存活白血病患儿与对照组儿童在恒牙龋失补(DMFT)和牙齿畸形方面的差异。

设计

本研究评估了 52 名长期存活白血病患儿(27 名女性,25 名男性;平均年龄 11.5 岁)的抗白血病治疗对牙齿发育的可能影响,并与 52 名健康对照组儿童(27 名女性,25 名男性,平均年龄 11 岁)进行比较。所有长期存活的白血病患儿均至少持续 24 个月完全缓解。通过常规口腔检查和全景片对患儿的口腔状况进行研究。记录 DMFT(根据世界卫生组织标准记录)和牙齿畸形,并进行评估。

结果

本研究结果表明,与对照组相比,长期存活白血病患儿发生龋齿的风险更高,且牙齿畸形更为严重,包括 V 形根、牙齿缺失、小牙、釉质发育不良等。

结论

血液疾病患儿在接受抗肿瘤治疗的同时,还需要特别注意口腔护理。因此,通过儿科血液肿瘤学家、儿科牙医和口腔卫生师之间的密切合作,可以保持口腔卫生和口腔健康。

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本文引用的文献

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Cancer statistics, 2010.癌症统计数据,2010 年。
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
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Childhood leukemia.儿童白血病
Pediatr Rev. 2010 Jun;31(6):234-41. doi: 10.1542/pir.31-6-234.
4
Acute myeloid leukemia.急性髓系白血病。
Hematol Oncol Clin North Am. 2010 Feb;24(1):35-63. doi: 10.1016/j.hoc.2009.11.008.

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