Faculty of Dentistry, Department of Periodontology, Gazi University, 8. Cadde 82. Sokak, 06510, Emek/Ankara, Turkey.
Faculty of Dentistry, Department of Oral & Maxillofacial Surgery, Gazi University, Ankara, Turkey.
Support Care Cancer. 2019 May;27(5):1891-1899. doi: 10.1007/s00520-018-4454-0. Epub 2018 Sep 10.
More attention has been focused on the long-term side effects of treatment protocols since impressive advances in childhood cancer treatment have resulted in a growing population of patients. The purpose of this study was to investigate the disturbances of dento-facial development in children who were long-term survivors of childhood malignancies.
Fifty-three children (mean age, 10 years + 4 months) in long-term remission underwent oral/dental and radiographic examinations after completion of therapy. Crown and root malformations, gingival/periodontal status, enamel defects, discolorations, decayed and unerupted teeth, premature apexifications, agenesis, maximal interincisal opening and lateral movement of jaws, and soft tissue abnormalities were noted. Caries were evaluated by the decayed-missing-filled teeth (DMFT) index. Forty healthy children (mean age, 12 years + 4 months) belonging to the same age group and socioeconomic community were served as controls. All participants in the study were evaluated in terms of craniofacial development.
The data of the study showed that higher prevalence of root malformation, unerupted teeth, and enamel hypoplasia were detected as a consequence of childhood cancer and/or antineoplastic therapy. Although no differences of craniofacial growth and development were observed between groups (P > 0.05), plaque and gingival index scores were statistically higher in the study group (P < 0.05).
A range of variations in dental structures is recognized as a side effect of childhood cancer therapy in long-term survivors of pediatric malignancies that may affect their quality of life.
由于儿童癌症治疗取得了令人瞩目的进展，导致患者群体不断增加，因此人们越来越关注治疗方案的长期副作用。本研究旨在调查长期儿童恶性肿瘤幸存者的牙颌面发育障碍。
53 名（平均年龄 10 岁+4 个月）处于长期缓解期的儿童在完成治疗后接受了口腔/牙科和影像学检查。记录了牙冠和牙根畸形、牙龈/牙周状况、牙釉质缺陷、变色、未萌出牙、早萌、缺失、最大切牙开口和颌骨侧向运动以及软组织异常。通过龋失补（DMFT）指数评估龋齿。40 名（平均年龄 12 岁+4 个月）来自同一年龄组和社会经济社区的健康儿童作为对照组。所有研究参与者均接受了颅面发育评估。
研究数据显示，儿童癌症和/或抗肿瘤治疗后，牙根畸形、未萌出牙和牙釉质发育不全的发生率更高。尽管两组之间的颅面生长发育无差异（P>0.05），但研究组的菌斑和牙龈指数评分更高（P<0.05）。
在儿科恶性肿瘤的长期幸存者中，一系列牙齿结构的变化被认为是儿童癌症治疗的副作用，可能会影响他们的生活质量。
