Institute of Stomatology, Nanjing Medical University, China.
Med Oral Patol Oral Cir Bucal. 2012 Nov 1;17(6):e962-8. doi: 10.4317/medoral.18168.
To investigate the association between semaphorin 3A (SEMA 3A) and its receptor neuropilin 1 (NRP1) and the clinicopathologic characteristics of patients with tongue cancer.
Forty-three tongue squamous cell carcinoma specimens were included. Immunohistochemical staining of SEMA3A and NRP1 was performed on 15 normal tongue epithelium specimens and the 43 tumour specimens. Immunoreactivity was evaluated based on the staining intensity and distribution score. Statistical analyses were performed using Chi-squared and Spearman tests and Kaplan-Meier analysis.
SEMA3A was significantly down-regulated in tongue cancer compared with normal tongue (P=0.025), while NRP1 was over-expressed in tumours (P<0.001). SEMA3A expression inversely correlated with nodal metastasis (P=0.017). NRP1 expression did not correlate with any clinicopathological characteristics. Higher SEMA3A expression strongly predicted longer survival (P=0.005). Scores for the NRP1/SEMA3A ratio of ≥1 predicted shorter survival (P=0.045).
Aberrant expression of SEMA3A and its receptor NRP1 might be involved in the development of tongue cancer and might be useful prognostic markers in this tumour type.
研究信号素 3A（SEMA3A）及其受体神经纤毛蛋白 1（NRP1）与舌癌患者临床病理特征的关系。
纳入 43 例舌鳞癌标本。对 15 例正常舌上皮标本和 43 例肿瘤标本进行 SEMA3A 和 NRP1 的免疫组织化学染色。根据染色强度和分布评分评估免疫反应性。采用卡方检验和斯皮尔曼检验以及 Kaplan-Meier 分析进行统计学分析。
与正常舌相比，舌癌中 SEMA3A 的表达明显下调（P=0.025），而 NRP1 在肿瘤中过表达（P<0.001）。SEMA3A 的表达与淋巴结转移呈负相关（P=0.017）。NRP1 的表达与任何临床病理特征均无相关性。较高的 SEMA3A 表达强烈预示着更长的生存时间（P=0.005）。NRP1/SEMA3A 比值评分≥1 预示着更短的生存时间（P=0.045）。
SEMA3A 及其受体 NRP1 的异常表达可能参与了舌癌的发生，并且可能是这种肿瘤类型有用的预后标志物。
