Department of Molecular Neuroscience, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada.
Neurochem Res. 2012 Dec;37(12):2805-13. doi: 10.1007/s11064-012-0874-2. Epub 2012 Aug 28.
The substantia nigra plays important roles in the brain function and is critical in the development of many diseases, particularly Parkinson's disease. Pathological changes of the substantia nigra have also been reported in other neurodegenerative diseases. Using a quantitative proteomic approach, we investigated protein expressions in the substantia nigra of Alzheimer's disease, Huntington's disease, and Multiple sclerosis. The expression level of one hundred and four proteins that were identified in at least three samples of each group were compared with the control group, with nineteen, twenty-two and thirteen proteins differentially expressed in Alzheimer's diseases, Huntington's disease and Multiple sclerosis respectively. The result indicates that the substantia nigra also undergoes functional adaption or damage in these diseases.
黑质在大脑功能中起着重要作用，是许多疾病（尤其是帕金森病）发展的关键。其他神经退行性疾病也报道了黑质的病理性变化。我们使用定量蛋白质组学方法研究了阿尔茨海默病、亨廷顿病和多发性硬化症患者黑质中的蛋白质表达。将每个组至少三个样本中的 104 种蛋白质的表达水平与对照组进行比较，分别在阿尔茨海默病、亨廷顿病和多发性硬化症中发现 19、22 和 13 种差异表达的蛋白质。结果表明，这些疾病也会导致黑质发生功能适应或损伤。
