Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, The Netherlands.
J Neurochem. 2019 Nov;151(4):435-445. doi: 10.1111/jnc.14603. Epub 2018 Nov 22.
Dementias are prevalent brain disorders in the aged population. Dementias pose major socio-medical burden, but currently there is no cure available. Novel proteomics approaches hold promise to identify alterations of the brain proteome that could provide clues on disease etiology, and identify candidate proteins to develop further as a biomarker. In this review, we focus on recent proteomics findings from brains affected with Alzheimer's Disease, Parkinson Disease Dementia, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. These studies confirmed known cellular changes, and in addition identified novel proteins that may underlie distinct aspects of the diseases. This article is part of the special issue "Proteomics".
痴呆症是老年人群中常见的脑部疾病。痴呆症给社会医疗带来了巨大的负担，但目前尚无有效的治疗方法。新的蛋白质组学方法有望识别大脑蛋白质组的改变，从而为疾病的病因提供线索，并鉴定候选蛋白作为进一步的生物标志物。在这篇综述中，我们重点介绍了受阿尔茨海默病、帕金森病痴呆、额颞叶痴呆和肌萎缩侧索硬化症影响的大脑的最新蛋白质组学发现。这些研究证实了已知的细胞变化，并发现了可能是这些疾病不同方面的基础的新蛋白质。本文是“蛋白质组学”特刊的一部分。
