Laboratory of Genetics, Immunology and Human Pathologies, Department of Biology, Tunis, Tunisia.
Arch Dermatol Res. 2012 Nov;304(9):733-8. doi: 10.1007/s00403-012-1279-4. Epub 2012 Aug 29.
An association between a common deletion comprising the late cornified envelope LCE3B and LCE3C genes (LCE3C_LCE3B-del) and psoriasis has been reported in Caucasian and Asian populations. To investigate whether this deletion plays a role in the genetic of psoriasis in Tunisian population, we determined the LCE3C_LCE3B-del genotype in 180 Ps patients and 208 healthy controls from different regions of Tunisia. The LCE3B and LCE3C gene variant was determined in the patients through PCR amplification and the SPSS software package. The frequency of the LCE3C_LCE3B-del was similar between patients and healthy controls. Subanalyses by family history revealed that the frequency of LCE3C_LCE3B-del was significantly higher in patients with a positive family history than in control individuals, as well as in individuals with a positive family history versus those without in the case cohort. However, no significant difference was observed between psoriatic patients with no family history and controls. We also evaluated the relationship between LCE3C_LCE3B-del and PSORS1. No significant epistatic effect was observed suggesting that there was no significant epistasis of the two loci in the Tunisian population. Our findings indicate that the LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population.
一个由晚期角蛋白包膜 LCE3B 和 LCE3C 基因（LCE3C_LCE3B-del）组成的常见缺失与银屑病的关联已在白种人和亚洲人群中报道过。为了研究这种缺失是否在突尼斯人群的银屑病遗传中起作用，我们在来自突尼斯不同地区的 180 名银屑病患者和 208 名健康对照者中确定了 LCE3C_LCE3B-del 基因型。通过 PCR 扩增和 SPSS 软件包在患者中确定了 LCE3B 和 LCE3C 基因变体。家族史的亚分析表明，阳性家族史患者的 LCE3C_LCE3B-del 频率明显高于对照个体，阳性家族史患者的频率也高于病例队列中无家族史患者。然而，在无家族史的银屑病患者和对照组之间没有观察到显著差异。我们还评估了 LCE3C_LCE3B-del 与 PSORS1 之间的关系。没有观察到显著的上位效应，表明这两个位点在突尼斯人群中没有显著的上位作用。我们的研究结果表明，LCE3C_LCE3B-del 可能在突尼斯人群的家族性银屑病中起作用。
