Ammar M, Bouchlaka-Souissi C, Soumaya K, Bouhaha R, Ines Z, Bouazizi F, Doss N, Dhaoui R, Ben Osman A, Ben Ammar-El Gaaïed A, Mokni M, Marrakchi R
Laboratory of Genetics, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Campus Universitaire, El Manar, 2092 Tunis, Tunisia.
Laboratory of Genetics, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Campus Universitaire, El Manar, 2092 Tunis, Tunisia.
Pathol Biol (Paris). 2014 Feb;62(1):34-7. doi: 10.1016/j.patbio.2013.10.003. Epub 2014 Jan 28.
Recently, it has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B-del) is associated with susceptibility to psoriasis in European and Asian populations. However, no study of this deletion has been performed in the North African population. The aim of the present study was to investigate whether this deletion is associated with familial psoriasis in Tunisian population.
A total of 34 patients and 55 healthy individuals were recruited from 7 multiplex families and a PCR assay was used to determine the association of this deletion. Its effect on susceptibility to psoriasis was assessed using the PDT program.
We failed to detect any evidence of association between LCE3C_LCE3B-del and psoriasis in Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus.
These findings indicate that the LCE3C_LCE3B-del does not contribute in a major way to psoriasis susceptibility in Tunisian families.
最近研究表明，晚期角质化包膜（LCE）基因簇中的一个缺失（LCE3C_LCE3B-del）与欧洲和亚洲人群的银屑病易感性相关。然而，尚未在北非人群中对该缺失进行研究。本研究的目的是调查该缺失是否与突尼斯人群中的家族性银屑病相关。
从7个多基因家族中招募了34例患者和55名健康个体，并使用聚合酶链反应（PCR）检测法来确定该缺失的相关性。使用PDT程序评估其对银屑病易感性的影响。
我们未能在突尼斯家族中检测到LCE3C_LCE3B-del与银屑病之间存在关联的任何证据。未发现该缺失与PSORS1位点之间存在上位效应。
这些发现表明，LCE3C_LCE3B-del对突尼斯家族的银屑病易感性没有主要影响。
