Suzuki N, Shinonaga M, Hirata K, Inoue S, Kuwabara T
Yokohama City University School of Medicine, Japan.
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1102-3. doi: 10.1136/jnnp.53.12.1102.
A case is presented of 14 year old female with hypothalamic obesity due to hydrocephalus caused by aqueductal stenosis. Evidence of hypothalamic obesity included 1) acute hyperphagia and weight gain, 2) neuroradiology showed hydrocephalus with focal enlargement of the third ventricle, 3) endocrinological studies revealed hyperinsulinaemia and impaired growth hormone (GH) response to arginine, but normal GH response to growth hormone-releasing factor (GRF) and 4) Torkildsen's ventriculo-cisternal shunting resulted in improvement in hyperphagia and obesity.
报告一例14岁女性因导水管狭窄导致脑积水引发下丘脑性肥胖。下丘脑性肥胖的证据包括:1)急性食欲亢进和体重增加;2)神经放射学检查显示脑积水伴第三脑室局灶性扩大;3)内分泌学研究显示高胰岛素血症以及生长激素(GH)对精氨酸的反应受损,但GH对生长激素释放因子(GRF)的反应正常;4)Torkildsen脑室-脑池分流术使食欲亢进和肥胖症状得到改善。