Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Chembiochem. 2012 Sep 24;13(14):2052-5. doi: 10.1002/cbic.201200429. Epub 2012 Aug 24.
Artificial influence: We describe a semi-artificial adenosylpeptide B(12) that behaves as a cofactor in B(12)-dependent enzymatic reactions and demonstrate that the peptide backbone influences its chemical properties and modulates its bioactivity in vitro and in vivo. Inhibition of the growth of L. delbrueckii is demonstrated, thus providing a potentially powerful approach for the development of antibacterial and antiproliferative compounds.
我们描述了一种半人工腺苷基肽 B(12)，它在 B(12)依赖性酶反应中充当辅因子，并证明肽骨架影响其化学性质，并调节其在体外和体内的生物活性。我们证明了它可以抑制 L. delbrueckii 的生长，因此为开发抗菌和抗增殖化合物提供了一种潜在的有力方法。
