Gubran Christopher, Narain Rajay, Malik Luqmaan, Saeed Saad Aldeen
Department of Gastroenterology, Walsall Manor Hospital, West Midlands, UK.
BMJ Case Rep. 2012 Aug 27;2012:bcr0220125931. doi: 10.1136/bcr-02-2012-5931.
Thyrotoxic periodic paralysis (TPP) is a rare metabolic disorder characterised by muscular weakness and paralysis in predisposed thyrotoxic patients. Although patients with TPP are almost uniformly men of Asian descent, cases have been reported in Caucasian and other ethnic populations. The rapid increase in ethnic diversity in Western and European nations has led to increase in TPP reports, where it was once considered exceedingly rare. Correcting the hypokalaemic and hyperthyroid state tends to reverse the paralysis. However, failure to recognise the condition may lead to delay in diagnosis and serious consequences including respiratory failure and death. We describe a young man who was diagnosed with hyperthyroidism who presented with acute paralysis. The clinical characteristics, pathophysiology and management of TTP are reviewed.
甲状腺毒症性周期性瘫痪（TPP）是一种罕见的代谢紊乱疾病，其特征为易感的甲状腺毒症患者出现肌肉无力和麻痹。尽管TPP患者几乎均为亚洲裔男性，但白种人和其他种族人群中也有病例报道。西方国家和欧洲国家种族多样性的迅速增加导致TPP报告增多，该疾病曾一度被认为极为罕见。纠正低钾血症和甲状腺功能亢进状态往往可使瘫痪症状逆转。然而，未能识别该病症可能导致诊断延迟以及包括呼吸衰竭和死亡在内的严重后果。我们描述了一名被诊断为甲状腺功能亢进并伴有急性瘫痪的年轻男性。本文对TPP的临床特征、病理生理学及治疗进行了综述。
