Kanagawa Y, Satake T, Kawashima R
Department of Animal Science, Faculty of Agriculture, Kyoto University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1990 Jun;36(3):243-9. doi: 10.3177/jnsv.36.243.
We investigated the role of thyroxine on bone growth in energy deficient rats. Rats were fed a normal diet and injected with saline, or a low-energy diet and injected with saline or 0.1, 1, or 5 micrograms/100 g BW of thyroxine for 22 days. Thyroxine injections decreased body weight gain but did not affect bone length and width. The epiphyseal growth plate was thinner and the activities of bone alkaline and acid phosphatase in energy deficient and 5 micrograms/100 g BW thyroxine injected animals were lower than that of the other treatment groups. Serum total thyroxine and triiodothyronine concentrations were increased but somatomedin C concentration was decreased by injecting with 5 micrograms/100 g BW of thyroxine in energy deficient rats.
我们研究了甲状腺素在能量缺乏大鼠骨骼生长中的作用。给大鼠喂食正常饮食并注射生理盐水，或者喂食低能量饮食并注射生理盐水或每100克体重0.1、1或5微克的甲状腺素，持续22天。注射甲状腺素会降低体重增加，但不影响骨骼长度和宽度。能量缺乏且注射5微克/100克体重甲状腺素的动物，其骨骺生长板更薄，骨碱性磷酸酶和酸性磷酸酶的活性低于其他治疗组。在能量缺乏的大鼠中，注射5微克/100克体重的甲状腺素会使血清总甲状腺素和三碘甲状腺原氨酸浓度升高，但生长调节素C浓度降低。
