蛋白质和/或能量缺乏对大鼠长骨生长的影响。

The influence of protein and/or energy deficiency on the growth of long bone in rats.

作者信息

Kuramitsu N, Matsui T, Yano H, Kawashima R

出版信息

J Nutr Sci Vitaminol (Tokyo). 1985 Apr;31(2):189-96. doi: 10.3177/jnsv.31.189.

DOI:10.3177/jnsv.31.189

Abstract

The effects of protein and/or energy deficiency on long bone growth were studied using rats of an average weight 100g. Four groups of Wistar rats were respectively fed on a normal diet, a low-energy diet, a low protein-diet, and a low-protein and low-energy diet for 45 days. Both energy and protein deficiency restricted gains of body weight and femur length and the activity of alkaline phosphatase in the tibia to the same extent. The epiphyseal growth plates of the femur in protein-deficient rats were as thin as those in energy-deficient rats. On the other hand, femur width and activity of acid phosphatase in the tibia were lower in protein-deficient animals than those in energy-deficient ones. Serum calcium concentrations and calcium content of bone were the same among all groups.

摘要

利用平均体重为100克的大鼠研究了蛋白质和/或能量缺乏对长骨生长的影响。将四组Wistar大鼠分别喂食正常饮食、低能量饮食、低蛋白饮食以及低蛋白和低能量饮食，持续45天。能量和蛋白质缺乏均在相同程度上限制了体重增加、股骨长度以及胫骨中碱性磷酸酶的活性。蛋白质缺乏大鼠的股骨骨骺生长板与能量缺乏大鼠的一样薄。另一方面，蛋白质缺乏动物的股骨宽度和胫骨中酸性磷酸酶的活性低于能量缺乏动物。所有组的血清钙浓度和骨钙含量相同。