Hermanns-Lê Trinh, Berardesca Enzo, Piérard Gérald E, Lesuisse Marianne, Piérard-Franchimont Claudine
Department of Dermatopathology, University Hospital of Liège, 4000 Liège, Belgium.
J Biomed Biotechnol. 2012;2012:413767. doi: 10.1155/2012/413767. Epub 2012 Aug 13.
In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.
在一些患者中，银屑病似乎对许多治疗都具有抗性，尤其是当疾病局限于某些特定身体部位时。在这方面，掌跖银屑病和掌跖脓疱病在其涉及白细胞介素-12、白细胞介素-23和辅助性T细胞17的免疫发病机制中可能是相关病症。甲银屑病和头皮银屑病是另外两种特殊的银屑病表现形式。因此，在其中一些患者中对乌司奴单抗进行了测试。本文仅限于同行评审的病例报告。数据未得到生物仪器评估和对照试验的支持。总体而言，它们表明了潜在疗效。成本效益以及风险效益评估值得进一步研究。
