挑战性区域银屑病与优特克单抗生物疗法：疾病模式的影响
Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease.
作者信息
Hermanns-Lê Trinh, Berardesca Enzo, Piérard Gérald E, Lesuisse Marianne, Piérard-Franchimont Claudine
机构信息
Department of Dermatopathology, University Hospital of Liège, 4000 Liège, Belgium.
出版信息
J Biomed Biotechnol. 2012;2012:413767. doi: 10.1155/2012/413767. Epub 2012 Aug 13.
Abstract
In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.
摘要
在一些患者中，银屑病似乎对许多治疗都具有抗性，尤其是当疾病局限于某些特定身体部位时。在这方面，掌跖银屑病和掌跖脓疱病在其涉及白细胞介素-12、白细胞介素-23和辅助性T细胞17的免疫发病机制中可能是相关病症。甲银屑病和头皮银屑病是另外两种特殊的银屑病表现形式。因此，在其中一些患者中对乌司奴单抗进行了测试。本文仅限于同行评审的病例报告。数据未得到生物仪器评估和对照试验的支持。总体而言，它们表明了潜在疗效。成本效益以及风险效益评估值得进一步研究。
相似文献
1
Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease.挑战性区域银屑病与优特克单抗生物疗法：疾病模式的影响
J Biomed Biotechnol. 2012;2012:413767. doi: 10.1155/2012/413767. Epub 2012 Aug 13.
2
Cost-efficacy comparison of biological therapies for patients with moderate to severe psoriasis in Japan.日本中重度银屑病患者生物疗法的成本效果比较。
J Dermatolog Treat. 2013 Oct;24(5):351-5. doi: 10.3109/09546634.2012.697111. Epub 2012 Jul 9.
3
Ustekinumab biotherapy and real-time psoriasis capacitance mapping: a pilot study.优特克单抗生物疗法与银屑病实时电容成像：一项初步研究。
J Biomed Biotechnol. 2012;2012:870194. doi: 10.1155/2012/870194. Epub 2012 Mar 27.
4
Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer.乌司奴单抗在银屑病免疫病理学中的作用，重点关注Th17-IL23轴：入门指南。
J Biomed Biotechnol. 2012;2012:147413. doi: 10.1155/2012/147413. Epub 2012 Jun 12.
5
Psoriasis: Is ustekinumab superior to etanercept for psoriasis?银屑病：优特克单抗治疗银屑病是否优于依那西普？
Nat Rev Rheumatol. 2010 Sep;6(9):500-1. doi: 10.1038/nrrheum.2010.134.
6
Ustekinumab: a review of its use in the management of moderate to severe plaque psoriasis.乌司奴单抗：在中重度斑块状银屑病治疗中的应用评价。
Drugs. 2011 Sep 10;71(13):1733-53. doi: 10.2165/11207530-000000000-00000.
7
Interventions for nail psoriasis.指甲银屑病的干预措施。
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD007633. doi: 10.1002/14651858.CD007633.pub2.
8
Ustekinumab: a new option in psoriasis therapy.优特克单抗：银屑病治疗的新选择。
Drugs. 2009 Jun 18;69(9):1141-52. doi: 10.2165/00003495-200969090-00001.
9
Concurrent treatment of chronic psoriasis and asthma with ustekinumab.乌司奴单抗治疗慢性银屑病合并哮喘。
J Dermatolog Treat. 2014 Feb;25(1):63-6. doi: 10.3109/09546634.2013.782095. Epub 2013 May 6.
10
Efficacy of ustekinumab in refractory palmoplantar pustular psoriasis.乌司奴单抗治疗难治性掌跖脓疱性银屑病的疗效。
Br J Dermatol. 2013 Apr;168(4):820-4. doi: 10.1111/bjd.12150.
引用本文的文献
1
SAPHO Syndrome: Current Developments and Approaches to Clinical Treatment.SAPHO 综合征：当前的研究进展和临床治疗方法。
Curr Rheumatol Rep. 2016 Jun;18(6):35. doi: 10.1007/s11926-016-0583-y.
2
Patient considerations and targeted therapies in the management of psoriasis in Chinese patients: role of ustekinumab.中国患者银屑病管理中的患者考量与靶向治疗：优特克单抗的作用
Patient Prefer Adherence. 2014 Jun 18;8:865-72. doi: 10.2147/PPA.S40638. eCollection 2014.
3
Treatment of nail psoriasis: common concepts and new trends.甲银屑病的治疗：常见概念与新趋势
Dermatol Res Pract. 2013;2013:180496. doi: 10.1155/2013/180496. Epub 2013 May 13.
本文引用的文献
1
Surface image analysis of nail alterations in juvenile pityriasis rubra pilaris.青少年毛发红糠疹指甲改变的表面图像分析
Skin Res Technol. 1998 Feb;4(1):34-6. doi: 10.1111/j.1600-0846.1998.tb00083.x.
2
Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer.乌司奴单抗在银屑病免疫病理学中的作用，重点关注Th17-IL23轴：入门指南。
J Biomed Biotechnol. 2012;2012:147413. doi: 10.1155/2012/147413. Epub 2012 Jun 12.
3
Investigator-initiated, open-label trial of ustekinumab for the treatment of moderate-to-severe palmoplantar psoriasis.研究者发起的、乌司奴单抗治疗中重度掌跖银屑病的开放标签试验。
J Dermatolog Treat. 2013 Jun;24(3):179-87. doi: 10.3109/09546634.2012.672710. Epub 2012 May 8.
4
Investigation of the hair of patients with scalp psoriasis using atomic force microscopy.应用原子力显微镜研究头皮银屑病患者的头发。
Clin Exp Dermatol. 2012 Mar;37(2):156-63. doi: 10.1111/j.1365-2230.2011.04212.x.
5
A comparative study of hair shafts in scalp psoriasis and seborrheic dermatitis using atomic force microscopy.头皮银屑病和脂溢性皮炎的毛发横切面的原子力显微镜比较研究。
Skin Res Technol. 2013 Feb;19(1):e60-4. doi: 10.1111/j.1600-0846.2011.00608.x. Epub 2012 Jan 4.
6
Recommendations for the treatment of nail psoriasis in patients with moderate to severe psoriasis: a dermatology expert group consensus.中重度银屑病患者甲银屑病治疗的推荐意见：一个皮肤科专家组的共识。
J Eur Acad Dermatol Venereol. 2012 Mar;26(3):373-81. doi: 10.1111/j.1468-3083.2011.04349.x. Epub 2011 Dec 10.
7
Efficacy of ustekinumab in nail psoriasis and improvement in nail-associated quality of life in a population treated with ustekinumab for cutaneous psoriasis: an open prospective unblinded study.乌司奴单抗治疗皮肤银屑病人群中指甲银屑病的疗效及对指甲相关生活质量的改善：一项开放性前瞻性非盲研究。
Dermatology. 2011;223(4):325-9. doi: 10.1159/000334482. Epub 2011 Nov 30.
8
Detailed analysis of specific nail psoriasis features and their correlations with clinical parameters: a cross-sectional study.详细分析特定的指甲银屑病特征及其与临床参数的相关性：一项横断面研究。
Dermatology. 2011;223(3):222-9. doi: 10.1159/000332974. Epub 2011 Nov 14.
9
Ustekinumab in clinical practice: response depends on dose and previous treatment.乌司奴单抗在临床实践中的应用：疗效取决于剂量和既往治疗。
J Eur Acad Dermatol Venereol. 2012 Apr;26(4):508-13. doi: 10.1111/j.1468-3083.2011.04325.x. Epub 2011 Nov 12.
10
Moderate to severe plaque psoriasis with scalp involvement: a randomized, double-blind, placebo-controlled study of etanercept.中重度斑块状银屑病伴头皮受累：依那西普的一项随机、双盲、安慰剂对照研究。
J Am Acad Dermatol. 2012 Jul;67(1):86-92. doi: 10.1016/j.jaad.2011.07.034. Epub 2011 Oct 20.
Zotero 插件