Maeda M, Fukui A, Inada Y, Tamai S, Mizumoto S
Department of Orthopaedic Surgery, Omiwa Hospital, Nara, Japan.
J Reconstr Microsurg. 1990 Jul;6(3):261-6. doi: 10.1055/s-2007-1006828.
In free tissue transfer, the recipient arteries and veins are often damaged by injury, and their lumens are often narrowed due to thickening of the intima. These factors are considered paramount in the poor success rate of free tissue transfers. In the reported study, the authors examined the effects of continuous intraarterial infusion with heparin and urokinase in experimental epigastric flap transfer. By intraarterial infusion, the drug concentration at the target site could be significantly increased. The viability of an epigastric flap transferred to a recipient site with thickened arterial intima was significantly improved in a rabbit model by a seven-day continuous local intraarterial infusion of heparin at 10 U/kg/hr and urokinase at 100 IU/kg/hr, compared with control or intravenous infusion. Use of an anticoagulant with a fibrinolytic enzyme is considered to be the best choice for a successful outcome in flap transfer.
在游离组织移植中，受区动脉和静脉常因损伤而受损，其管腔常因内膜增厚而变窄。这些因素被认为是游离组织移植成功率低的首要因素。在该报道的研究中，作者研究了在实验性腹壁皮瓣移植中持续动脉内输注肝素和尿激酶的效果。通过动脉内输注，靶部位的药物浓度可显著提高。在兔模型中，与对照组或静脉输注相比，通过以10 U/kg/小时的剂量持续7天局部动脉内输注肝素和以100 IU/kg/小时的剂量持续7天局部动脉内输注尿激酶，转移至动脉内膜增厚的受区部位的腹壁皮瓣的存活能力得到显著改善。使用抗凝剂和纤维蛋白溶解酶被认为是皮瓣移植成功的最佳选择。
