Okamoto Y, Nakajima T, Yoneda K
Department of Plastic and Reconstructive Surgery, Fujita Health University School of Medicine, Aichi, Japan.
Ann Plast Surg. 1993 Feb;30(2):154-8. doi: 10.1097/00000637-199302000-00010.
Prostaglandin E1 has been proven to be useful in the treatment of vascular diseases of the lower leg. Plastic surgeons have been aware of its usefulness in augmenting flap survival and have used it intraarterially or intravenously. We attempted to enhance the effect of prostaglandin E1 with heparin by local continuous intraarterial infusion of both drugs. First, we assessed the viability area of an experimental island flap model on rabbit abdomen, and confirmed the usefulness of this method. Next, we attempted to develop clinical cases using Seldinger's method. By this method, we were able to rescue the flaps with circulatory insufficiency and gain a larger survival area of an axial pattern flap.
前列腺素E1已被证明在治疗小腿血管疾病中有用。整形外科医生已经意识到它在提高皮瓣存活率方面的作用，并已通过动脉内或静脉内使用。我们试图通过局部持续动脉内输注肝素和前列腺素E1来增强前列腺素E1的效果。首先，我们评估了兔腹部实验性岛状皮瓣模型的存活面积，并证实了该方法的有效性。接下来，我们尝试使用Seldinger法开展临床病例。通过这种方法，我们能够挽救循环不足的皮瓣，并获得更大面积的轴型皮瓣存活。
