Brown Sheena D, Calvert H Hardie, Fitzpatrick Anne M
Dermatoendocrinol. 2012 Apr 1;4(2):137-45. doi: 10.4161/derm.20434.
Asthma, one of the most prevalent diseases affecting people worldwide, is a chronic respiratory disease characterized by heightened airway inflammation, airway hyperresponsiveness and airflow obstruction in response to specific triggers. While the specific mechanisms responsible for asthma are not well understood, changing environmental factors associated with urban lifestyles may underlie the increased prevalence of the disorder. Vitamin D is of particular interest in asthma since vitamin D concentrations decrease with increased time spent indoors, decreased exposure to sunlight, less exercise, obesity, and inadequate calcium intake. Additionally, a growing body of literature suggests that there is a relationship between vitamin D status and respiratory symptoms, presumably through immunomodulatory effects of vitamin D. This review discusses vitamin D as it relates to asthma across the age spectrum, with a focus on human studies.
哮喘是影响全球人群的最常见疾病之一，是一种慢性呼吸道疾病，其特征为气道炎症加剧、气道高反应性以及对特定触发因素产生气流阻塞。虽然导致哮喘的确切机制尚未完全明确，但与城市生活方式相关的环境因素变化可能是该疾病患病率上升的原因。维生素D在哮喘方面备受关注，因为随着室内停留时间增加、阳光照射减少、运动量减少、肥胖以及钙摄入不足，维生素D浓度会降低。此外，越来越多的文献表明，维生素D状态与呼吸道症状之间存在关联，可能是通过维生素D的免疫调节作用实现的。本综述讨论了维生素D与各年龄段哮喘的关系，重点是人体研究。
