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乳酸克鲁维酵母：一种研究细胞防御机制对抗低氧诱导氧化应激的合适酵母模型。

Kluyveromyces lactis: a suitable yeast model to study cellular defense mechanisms against hypoxia-induced oxidative stress.

机构信息

Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña, Coruña, Spain.

出版信息

Oxid Med Cell Longev. 2012;2012:634674. doi: 10.1155/2012/634674. Epub 2012 Jul 2.

DOI:10.1155/2012/634674
PMID:22928082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3425888/
Abstract

Studies about hypoxia-induced oxidative stress in human health disorders take advantage from the use of unicellular eukaryote models. A widely extended model is the fermentative yeast Saccharomyces cerevisiae. In this paper, we describe an overview of the molecular mechanisms induced by a decrease in oxygen availability and their interrelationship with the oxidative stress response in yeast. We focus on the differential characteristics between S. cerevisiae and the respiratory yeast Kluyveromyces lactis, a complementary emerging model, in reference to multicellular eukaryotes.

摘要

关于人类健康紊乱中缺氧诱导的氧化应激的研究，利用单细胞真核生物模型具有优势。一个广泛扩展的模型是发酵酵母酿酒酵母。在本文中，我们描述了由氧气供应减少引起的分子机制及其与酵母中氧化应激反应的相互关系的概述。我们专注于酿酒酵母和呼吸酵母乳酸克鲁维酵母之间的差异特征，这是一个互补的新兴模型，涉及多细胞真核生物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c6/3425888/612675e46459/OXIMED2012-634674.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c6/3425888/edf7a879d94c/OXIMED2012-634674.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c6/3425888/612675e46459/OXIMED2012-634674.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c6/3425888/edf7a879d94c/OXIMED2012-634674.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c6/3425888/612675e46459/OXIMED2012-634674.002.jpg

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