Salloway Stephen
Warren Alpert Medical School of Brown University, USA.
Med Health R I. 2012 Jul;95(7):207-9.
Dementia syndromes usually consist of distinct clinical and pathological phenotypes. A careful history is required to document the onset and progression of symptoms to generate the differential diagnosis. New biomarker tests can provide evidence to increase diagnostic certainty. Disease-specific interventions, based on advances in genetic and molecular biomarkers, are likely to have the greatest impact when given in preclinical and early symptomatic phases.
痴呆综合征通常由不同的临床和病理表型组成。需要仔细询问病史以记录症状的发作和进展情况，从而进行鉴别诊断。新的生物标志物检测可为提高诊断确定性提供证据。基于遗传和分子生物标志物的进展而开展的针对特定疾病的干预措施，在临床前和症状早期阶段实施时可能会产生最大影响。
